Recordings of our live webinars with autism and gut health researchers, available to watch anytime.
In this recorded session, Dr. Anjum Usman Singh explores the emerging science connecting gut bacteria to serotonin, dopamine, and other neurotransmitter pathways in children with autism, and shares practical concepts parents can discuss with their child's healthcare provider.
Dr. Anjum Usman Singh · MD, FAAFP, ABIHM, Hom-C, FMAPS
Watch the Recording
In this recorded session, Dr. James B. Adams covers the research behind the MDM™ Gut and Brain Health Test, how families can order it, and what the results can tell you.
Dr. James B. Adams · President of Autism Diagnostics Lab
Watch the RecordingConversations with Autism Diagnostics Lab on leading autism podcasts — available to watch or listen anytime.
Dr. James B. Adams joins Lisa Ackerman on TACA’s Moving Autism Forward podcast to discuss the gut–brain connection in autism and our new urine-based MDM™ test for microbial metabolites.
Dr. James B. Adams · President of Autism Diagnostics Lab
See exactly what your results will look like, including bacterial and yeast markers, reference ranges, flagged values, and your personalized MDM Dysbiosis Score.
View Full Sample ReportSample data shown for illustration purposes only. This is not an actual patient result.
Alongside the full metabolite breakdown, every report includes one simple summary score. It shows how many of the tracked bacterial and yeast markers fall outside the normal range, giving you a quick, at a glance view of overall gut balance.
This compound is made from tryptophan and may also be influenced by yeast activity in the gut. High levels may affect normal metabolism and brain function, although its effects are not yet well understood.
An elevated level of 2-Hydroxyphenylacetic acid (2-HPAA) frequently signals intestinal dysbiosis or bacterial overgrowth of the small intestinal. This occurs when an overgrowth of unhealthful microbial flora in the intestines actively breaks down amino acids, particularly phenylalanine. By intercepting these nutrients before absorption, the microbial flora produce excess 2-HPAA as a byproduct and deplete the amino acids, often leading to low tyrosine levels.
IPA is made when certain gut bacteria break down tryptophan. It can have beneficial effects in normal amounts, but abnormal levels may be a sign that the gut microbiome is out of balance.
IAN is related to tryptophan metabolism and can come from both gut microbes and certain foods. Abnormal levels may reflect changes in diet or the gut microbiome, but its effects on the body are still not well understood.
5-MIAA is a compound related to tryptophan metabolism that may be influenced by the gut microbiome. Abnormal levels may be a sign that the way tryptophan is being processed has changed.
Hippuric acid is produced when the body processes compounds that often come from food and gut bacteria. Abnormal levels may reflect changes in the gut microbiome or in the body's ability to process these compounds.
IAA is produced when gut bacteria break down tryptophan. Abnormal levels may reflect changes in the gut microbiome and may affect communication between the gut, immune system, and brain.
IAG is produced when gut bacteria break down tryptophan. Abnormal levels have been associated with digestive problems and changes in the intestinal barrier.
This compound is produced when gut microbes break down tryptophan. It may help support the intestinal lining and immune system, while abnormal levels may indicate changes in gut microbial activity.
ILA is made by several types of gut bacteria and may help support normal immune and intestinal function. Abnormal levels may reflect changes in the gut microbiome and its communication with the body.
Indoxyl sulfate is harmful to the body, and is produced when gut bacteria break down tryptophan and the body processes the resulting compounds. High levels may be harmful and have been associated with oxidative stress, mitochondrial problems, and changes in gut and immune function.
Methyl 3-indole acetate is produced through bacterial metabolism and has been found at high levels in some people with autism. High levels may be a sign of an imbalance in gut microbial activity.
HPHPA is produced by certain gut bacteria and has been associated with changes in gut health and behavior. High levels may indicate an imbalance in the gut microbiome.
P-cresol sulfate is a harmful compound produced when gut bacteria break down certain amino acids and the body processes the resulting compounds. High levels are likely harmful and have been associated with oxidative stress, mitochondrial problems, and gut imbalance.
Arabinitol is produced mainly by yeast and fungi, including Candida. High levels may be a sign of increased yeast or fungal activity in the gut.
Citramalic acid is associated with yeast activity and has been found at higher levels in some people with autism. High levels may interfere with the body's normal energy-producing pathways.
Tartaric acid can come from foods, but high levels may also be associated with increased yeast or fungal activity. Large amounts may interfere with normal energy production and the body's use of important minerals.
Produced by aerobic bacteria, yeast, or Aspergillus species (mold). It binds to magnesium, potentially leading to a magnesium deficiency.
4-EPS is produced when gut bacteria make certain compounds that are later processed by the body. High levels may indicate changes in the gut microbiome and have been linked in animal studies to changes in brain function and behavior.
A bacterial metabolite linked to urea cycle disorders and the removal of neurotoxic ammonia waste from the body. When a patient presents to an emergency room in hyperammonemia crisis, doctors administer sodium benzoate to remove excess NH4+. Phenylacetylglutamine is detected in urine.
Phenylalanine is an essential amino acid that the body uses to make important brain chemicals and hormones. Abnormal levels may result from diet, metabolism, or changes in how gut microbes use this amino acid.
Tryptophan is an essential amino acid used to make important compounds involved in sleep, mood, immune function, and brain health. Gut microbes also use tryptophan, so abnormal levels may reflect changes in the balance between human and microbial metabolism.
Tyrosine is an amino acid needed to make important brain chemicals and thyroid hormones. Abnormal levels may be related to diet, metabolism, or changes in how gut bacteria process tyrosine.
